17-OHPC Apgar score Lactobacillus MMP-8 MMP-9 Medicine antenatal corticosteroids betamethasone elastography extreme preterm birth gestational age high-risk patients high-risk pregnancy long-term follow-up metalloproteinases microbiome micronized progesterone mortality neurologic morbidity neurological neurological morbidities offspring ophthalmic morbidities pediatric pediatric hospitalization perinatal mortality perinatal outcomes placental abruption population-based study preeclampsia