BRAFV600E COLD-PCR EU-TIRADS FCH FEC Medicine PET-CT PTC S-Detect Snail-1 care pathway complications computer-aided diagnosis digital PCR ectopic mediastinal localization ectopic thymus fine-needle aspiration cytology guidelines hyperparathyroidism interobserver variability liquid biopsy loss of signal metastasis metastatic lymph nodes papillary thyroid cancer parathyroid adenoma parathyroid scintigraphy parathyroid sonography parathyroidectomy persistent hypercalcemia