FeNO IL-1β Medicine NLRP3 PBMC PreDicta acute severe asthma exacerbation adhesion airway remodeling airway smooth muscle cell allergic airway inflammation alternative overlap syndrome alveolar macrophages anti-IL-5 asthma asthma-specific quality of life bronchial asthma bronchial biopsies bronchodilation children chronic rhinitis clinical remission disease-specific quality of life eosinophil exacerbation health-related quality of Life (HRQLQ) hypercapnia hyperchloremic acidosis hypocapnia immune regulation