ALK DOAC DOACs Hodgkin lymphoma KRAS Medicine Non-Hodgkin lymphoma Oncology ROS1 UFH VKA VTE anticoagulants arterial thrombosis cancer cancer associated thrombosis cancer-associated venous thromboembolism chemotherapy coagulation activation coumarins deep vein thrombosis direct oral anticoagulant direct oral anticoagulants endogenous heparin heparan sulfate heparanase hospice integrated care locally advanced breast cancer low molecular weight heparin