Brassica napus CRISPR/Cas9 CRISPR/Cas9 site directed mutagenesis F1 hybrids GWAS GmDof11 GmDof4 ISSR Japanese plum PPR genes Pentatricopeptide Repeats QTL QTL/genes RNA editing RNA-seq Rf1 gene SNP SSR TGW6 Wx abscisic acid amylose content anther association mapping bioinformatics breeding scheme brown midrib candidate genes cell wall climate change