Box-Behnken design Calliblepharis jubata Phaedactylum tricornutum Rhodotorula sp Technology: general issues Vibrio mediterranei anti-enzymatic activity anti-inflammatory activity antimicrobial activity antioxidant antioxidant activity aquaculture bioactive compounds canthaxanthin carbohydrates carotenoids carrageenan co-solvent commercial microalgae cultivation complete genome cosmetics cytotoxicity dietary supplements docosahexaenoic acid (DHA) extraction conditions fatty acids fucoxanthin giant phage invasive seaweed lutein production