C-reactive protein Candida bloodstream infection ICU Klebsiella NDM MR-proADM MRproAdrenomedullin Medicine Presepsin afebrile patients antifungal stewardship antimicrobial stewardship antioxidant therapy blood purification ceftazidime-avibactam chemotherapy-induced damage critical care critically ill patients echinocandin emergency department extracorporeal immune modulation fever immunomodulation infection infections intensive care internal medicine micronutrients mitochondria multidrug-resistant bacteria multiple organ failure