COVID-19 Cardiovascular medicine Crohn's disease GWAS Medicine PRS accelerated atherosclerosis acute coronary syndrome atherosclerosis biomarkers cancer carbon monoxide poisoning cardiac dysfunction cardiotoxicity cardiovascular risk chemotherapy chronic coronary syndrome coronary artery disease coronary spasm coronary thrombosis cytokines elderly electrocardiography endothelial dysfunction frailty genetic risk factors heart failure heritability inflammation inflammatory bowel disease