C-peptide Oral antimicrobials aerogel amphiphilic random copolymers anticancer antimicrobial photodynamic therapy astaxanthin autophagy induction betulinic acid biofilms bolaform amphiphilic lipids bolalipids caries prevention chitosan chorioallantoic membrane model controlled release curcumin diabetes diffusion barrier doxorubicin drug delivery drug delivery system drug delivery systems encapsulation eukaryotic vaults gold nanoparticles gold reduction graphene quantum dots hyaluronan hydrogel