CAD CHD CKD COPD CYP450 eicosanoids EEQs EETs FADS Genome-wide association study (GWAS) Insulin sensitivity Mediterranean diet PUFA adipose tissue alternatively activated macrophages antioxidant arachidonic acid blood lipids blood pressure body weight cardiometabolic disease cardiovascular disease children cholesterol ester cohort study conjugated fatty acids coronary artery disease desaturase diet docosapentaenoic acid epidemiology