(−)-majusculoic acid ADMET Avicennia alba CCK-8 Chemistry In-silico drug design LPS Research & information: general animal studies anti-inflammation aureol biological activity biosynthesis cancer cardiovascular diseases chemical synthesis cyclomarins cyclopeptides divergent total synthesis gag polyprotein homology modeling ilamycins inflammation malaria marine alkaloids marine natural products molecular dynamics simulation natural products rufomycins tetracyclic meroterpenoids