3-hydroxy-3-methylglutaryl AMC Charcot-Marie-Tooth disease Duchenne muscular dystrophy ECEL1 GAA gene Medicine Neurology & clinical neurophysiology Pompe disease adolescents brachial plexus neuritis carpal tunnel syndrome carrier frequency chaperone-assisted autophagy child neurology children clinical course clinical trials coenzyme A reductase contractures distal arthrogryposis electrodiagnostic studies fine manual dexterity general population database genetic prevalence hereditary sensory and motor neuropathy inflammatory neuropathy juvenile myositis kyphosis median nerve neuropathy