Alzheimer disease Alzheimer's disease Amaryllidaceae Chemistry MD simulations Medicine N-methyl-d-aspartate receptor Narcissus pseudonarcissus cv. Carlton acetylcholinesterase acetylcholinesterase inhibitor acetylcholinesterase inhibitors alkaloids antioxidants behavior blood-brain barrier crossing bone healing butyrylcholinesterase butyrylcholinesterase inhibitors carltonine A-C catalysis cholinesterase dementia docking docking studies donepezil fluorene hemostasis hydrolysis in silico in vitro