C2_2E12 Chemistry Fc binding G protein-coupled receptor HPV cancer therapy HPV oncoproteins HPV-associated cancer Human papillomaviruses Research & information: general SARS-CoV-2 ST2 receptor T-cell-receptor-like antibody VEGF affinity maturation agonist antibody anti-angiogenesis anti-cancer antibody antibodies antibody antibody engineering antibody therapeutics antibody therapy antibody-drug conjugates antigen asthma atherosclerosis binding assays bioassays biochemical and physicochemical properties biomarker