ECM EMT G protein-coupled receptor GPCR Hippo Hippo pathway Hippo signalling LATS LATS (large tumor suppressor kinase) LATS1/2 Lats2 MST MST (mammalian STE20-like protein kinase) MST1/2 Mps one binder NDR STK38 STRIPAK TAZ TAZ (transcriptional co-activator with PDZ-binding motif) TEAD Taz YAP YAP (yes-associated protein) YAP/TAZ Yap adaptive immunity angiogenesis anti-cancer therapy autoimmunity