BNP Medicine NOAC SNPs VKA ablation acute myocardial infarction age anticoagulation antiplatelet therapy arrhythmia atrial cardiopathy atrial fibrillation atrial remodeling atrial tachycardia autonomic nervous system biomarkers bleeding risk cardiac cardiac ablation cardiac remodeling catheter ablation circRNA convergent ablation coronary artery bypass grafting coronary artery disease dementia early-onset elderly electroporation