Addison’s disease GBM-associated macrophages (GAMs) Interleukin-6 Medicine PD-1 PD-L1 STAT3 inhibitor TAM Treg VEGF adrenal insufficiency bevacizumab cerebral radiation necrosis checkpoint inhibitors craniopharyngioma diffusion tensor imaging exosomes generalized q-ball imaging glioblastoma multiforme (GBM) glioma high-grade glioma inflammation multiple resections oncoantigen oncomiR-21 pituitary neuroendocrine tumors treatment-related effects tumor angiogenesis tumor associate antigen tumor microenvironment (TME)