Grüneisen parameter Negative thermal expansivity ab initio calculation antifreeze protein clathrate hydrate coarsening kinetics cryo-photo microscopy cryoprotective agent decomposition deformation electron paramagnetic resonance formation freezing gas hydrate ice cream ice crystal ice crystals mW model microstructure modelling molecular dynamics nanoscale pores potential of mean force pre-decomposition pressure pressure quasi-liquid layer reformation spin labeling tetrahydrofuran tomography