Active sites Catalysis HIV/AIDS L-proline Metalloenzymes Quality by Design Reactions and Mechanisms Research & information: general Science: general issues X-ray Diffraction barbituric acid cocrystal cocrystals compaction crystal engineering crystal structure crystallization inhibitors design of experiments diclofenac sodium dissolution dissolution behavior dissolution rate drug-polymer interactions formulation imidazole N-oxides interparticulate bonding area interparticulate bonding strength itraconazole lamivudine mechanochemistry