Alzheimer's disease COVID-19 Caenorhabditis elegans E551 European Chemicals Agency (ECHA) Medicine NALP3 NR8383 Raphidocelis subcapitata SiO2 aggregation air pollution amyloid best practice biocompatibility bone marrow derived macrophages cell death circulating tumor cells co-exposure colon cells cytotoxicity dementia diabetes ecotoxicology genotoxicity hyperglycemic response in vitro toxicity inter-laboratory comparison interleukin-1beta intestine