APOE IPMK SNP TERC TERT age-stratification aging apolipoprotein E cardiovascular health cumulative incidence curves exceptional longevity gender-specific association genetic association study genetic determinants of human longevity genetic variation genomics human lifespan inositol phosphates leukocyte telomere length lifespan lipid profile long-livers longevity longevity-related genes model systems molecular senescence moonlighting protein mortality polygenic risk score polymorphism