CFD Central Coast of California Lachancea Merlot Ontario Pinot noir Saccharomyces Saccharomyces bayanus anthocyanins appassimento aroma classical chemical analysis climate change adaptation cluster thinning color color intensity crop load elemental sulfur end-user software extraction extraction methods fermented drinks glycosidase grape maturity metabolic modelling metabolite profiling metabolomics microwave microwave-assisted extraction non-Saccharomyces yeasts