3D CLEM Co-Fe ferrite nanoparticles DNA damage EGFR-targeting History of engineering & technology MR-guided radiotherapy Monte Carlo simulation NIR triggering NIR-triggered Technology: general issues alternative therapy anisotropy application bio-application bio-imaging biomedical imaging cancer cancer therapy cancer treatment colon cancer cells correlative microscopy deep tissue dose enhancement drug delivery drug release gold nanoparticle gold nanoparticles gold nanorods immunotherapy light scattering