2D INADEQUATE Adenylate kinase DNA DNP Dihydrofolate reductase MARK2 phosphorylation NMR spectroscopy Ribosome Tau Thioredoxin Thymidylate synthase antimicrobial peptide cross-correlated relaxation crystalline and amorphous starch drug discovery enzyme activity enzyme kinetics in-cell NMR in-situ NMR intrinsically disordered proteins lipid membrane live cell mRNA magic-angle spinning mammalian cells non-uniform sampling 2 paramagnetic effects post-translational modifications protein NMR protein dynamics